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Price of generic atorvastatin ) than non-medically managed patients with high cholesterol (≥150 mg/dL) and low-density lipoprotein cholesterol levels >2.5 mmol/L (≥300 mg/dL). The authors further hypothesize that reduction in overall mortality observed patients with cardiovascular disease may be due to a lower incidence of cardiovascular events in these patients. This randomized, placebo-controlled trial was conducted in patients with stable hypercholesterolemia between the ages of 40 and 70 years with coronary artery disease. Patients were randomly assigned to receive either a 500 mg single-dose, double-blinded, placebo or active drug. The study design involved 3 phases. Phase I a 12-week, randomized, double-blinded, placebo-controlled phase followed by a 30-week, randomized, multicentre parallel-group, placebo-controlled phase. Phase II used a placebo-controlled primary outcomes period consisting of a 12-week, randomized, double-blinded, placebo-controlled phase followed by a 24-week, randomized, double-blinded multicentre phase. In this study, the investigators found that efficacy of atorvastatin was associated with reductions in cardiovascular events and mortality. The study was also free of any major adverse events. In post-hoc analyses the authors found that a 1-fold increase in the number of participants with a cardiovascular event during the placebo phase increased proportion of participants who required a placebo-controlled primary outcome phase by 1.4% (9 of 10,738 events/1.4%) compared to participants with ≥1 cardiovascular event on the active drug. researchers also determined that a 1-fold decrease in cardiovascular events during the placebo Phase I (12 weeks) was associated with a decrease of 1.1% (23 deaths/1.0%) in the proportion of participants who required a primary outcome Phase II (30 weeks) compared to participants with ≥1 cardiovascular event on the active drug. Based on the study findings, investigators concluded that the efficacy of atorvastatin in patients with cardiovascular disease was associated reductions in cardiovascular events and mortality. The magnitude of clinical effect was greater than that reported for fibrates and statins in previous trials, greater than that reported for niacin and vitamin D in other studies. The researchers suggested that, based on this study, atorvastatin may be an effective therapy for lowering the incidence of cardiovascular events and mortality in patients with cholesterol levels over 150 mg/dL with a stable blood cholesterol level of 150 mg/dL or less. To support this hypothesis, the investigators undertook a more recent, 2-site trial in which they randomly assigned 1,066 patients, 50% of whom received a placebo, and 50% atorvastatin as the primary treatment. In this study, the results of which were published in August 2013, the investigators found efficacy for atorvastatin was associated with reductions in cardiovascular events, death, and non-fatal myocardial infarction (NFI). For all-cause mortality, they reported a reduction in absolute risk of cardiovascular death 17%, relative risk reduction of 1.4% when compared with placebo and a 3.0% relative risk reduction when compared with a placebo What over the counter drug is like zovirax 2.0% absolute risk reduction and a 2.4% relative risk reduction when compared with an active drug for all-cause mortality. myocardial infarction, patients treated with atorvastatin reduced the absolute risk of myocardial infarction by 5% relative risk reduction when compared with placebo and 14% relative risk reduction when compared with a placebo an absolute risk reduction of 4.0%. Finally, the researchers noted that for all-cause mortality, atorvastatin reduced the absolute risk of event by 7% when compared with placebo and 9% when compared with a placebo drug an absolute risk reduction of 9.1%. Although the findings of these 2 clinical trials differ significantly, Atorva 60 Pills 70mg $490 - $8.17 Per pill one of them does provide some support to the hypothesis that a combination of atorvastatin and statin may be a feasible treatment for lowering cholesterol. In both trials, the patients who remained on current treatment were more stable, had less serious cardiovascular events, and had lower mortality compared to those who were not using statins. However, the differences between studies were minimal and would be insufficient to change the overall results of study. Based on these results, the Cochrane Collaboration and other authors have suggested that it is too soon to make a recommendation as whether statins are helpful or ineffective for lowering cholesterol (2, 6, 7). For more information on the use of statins for lowering cholesterol please see the following articles in this Special Section: 1. Burch, P., et al. "The role of cholesterol-lowering statins in the primary prevention of cardiovascular disease." JAMA. 2014;

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